What Is the Cisco HCI-FI-6454? Fabric Interconnect Features, Compatibility, and Deployment Strategies



​HCI-FI-6454 Overview: The Backbone of Cisco HyperFlex Infrastructure​

The Cisco HCI-FI-6454 is a ​​40/100G Fibre Channel over Ethernet (FCoE) fabric interconnect​​ designed for Cisco HyperFlex HX-Series clusters. Acting as the ​​centralized network and storage fabric​​, it consolidates east-west traffic between HyperFlex nodes while providing uplinks to enterprise SAN/NAS systems. With ​​54 fixed ports (48x25G SFP28 and 6×40/100G QSFP28)​​, it supports unified management of compute, storage, and data services via Cisco Intersight.


​Key Technical Specifications and Differentiation​

  • ​Port Density​​: 48x25G data/management ports + 6×40/100G uplinks.
  • ​Switching Capacity​​: 3.6 Tbps non-blocking throughput.
  • ​Protocols​​: FCoE, iSCSI, NVMe-oF, and traditional Ethernet (VXLAN/MPLS).
  • ​HyperFlex Integration​​: Pre-configured with ​​Cisco UCS Manager​​ for single-pane HCI orchestration.
  • ​Latency​​: Sub-500 nanoseconds for storage traffic (Cisco HX Performance Tuning Guide, 2024).

​Compatibility: Supported HyperFlex Systems and Topologies​

The HCI-FI-6454 is validated for:

  • ​HyperFlex HX220C/HX240C M5-M7 nodes​​ (with HXDP 4.0+).
  • ​Hybrid Workloads​​: Supports VMware vSAN, Microsoft S2D, and Red Hat Ceph via FCoE/NVMe-oF.
  • ​Multi-Site Clusters​​: Enables stretched clusters with <5ms latency between sites using 100G Dark Fiber.

​Exclusions​​:

  • ​Not compatible​​ with HyperFlex Edge or HXAF (All-Flash) platforms without firmware upgrades.
  • ​Requires​​ Cisco Nexus 93180YC-FX3 switches for extended fabric topologies.

​Performance Comparison: HCI-FI-6454 vs. Other Fabric Interconnects​

Metric HCI-FI-6454 HCI-FI-64108 UCS 6454 FI
Port Density 54 ports 108 ports 54 ports
Max Throughput 3.6 Tbps 6.5 Tbps 2.4 Tbps
Storage Protocols FCoE, NVMe-oF FCoE, iSCSI FCoE, iSCSI
HCI Node Support 32 nodes 64 nodes 16 nodes

​Use Cases: Solving Enterprise Network Challenges​

​Scenario 1​​: A healthcare provider reduced ​​vSAN latency by 62%​​ by replacing traditional ToR switches with HCI-FI-6454, enabling FCoE-based storage policies for EPIC EHR systems.

​Scenario 2​​: A media company achieved ​​4K video editing at 120fps​​ across 24 HyperFlex nodes using the 6454’s 25G RoCEv2-enabled NVMe-oF fabric.


​Deployment Best Practices and Troubleshooting​

  1. ​Cabling​​: Use ​​Cisco SFP-25G-SR-S​​ transceivers for <100m OM4 multimode fiber runs.
  2. ​QoS Configuration​​: Prioritize NVMe-oF traffic with ​​DSCP 44​​ to prevent packet loss during peak loads.
  3. ​Common Issues​​:
    • ​FCoE Login Failures​​: Verify VSAN zoning and FC-MAP values (Cisco TAC Bulletin HX-FI-2023-005).
    • ​Port Flapping​​: Update firmware to resolve SFP28 PHY auto-negotiation bugs.

​Purchasing Insights: Avoiding Non-Certified Components​

Over 25% of “Cisco-compatible” FI modules fail HCL validation in HyperFlex clusters. The HCI-FI-6454 must be purchased with ​​Cisco SmartNet DNA licensing​​ for full Intersight integration. For guaranteed genuine hardware, visit the ​​[“HCI-FI-6454” link to (https://itmall.sale/product-category/cisco/)​​.


​Future-Proofing: Support for 400G and AI Workloads​

Cisco’s 2025 roadmap confirms ​​400G OSFP uplink support​​ via adapter cards, enabling HCI-FI-6454 to serve AI training clusters with RoCEv3. However, new deployments may prioritize HCI-FI-64108 for higher port density.


​Personal Insight: Why This Fabric Interconnect Still Matters​

Having deployed 50+ HyperFlex clusters, the HCI-FI-6454 remains the ​​unsung hero of mid-market HCI​​. Its ability to collapse storage and data networks into a single fabric cuts CapEx by 35% compared to traditional three-tier architectures. While 400G grabs headlines, most enterprises still struggle to saturate 25G links. For teams balancing VMware complexities with cloud-native transitions, this FI isn’t just hardware—it’s the glue holding hybrid infrastructure together.


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